I had to Google to find out what an Oxford comma was. Never heard of it before. And my secondary school English teachers would have been horrified at its use. Absolutely no final comma before an “and”, for example.
By the by, when I started writing books I bought myself a style guide. I bought the one published by my normal newspaper, The Guardian. Fortunately, for this forum, its reference is food related - “A comma before the final ‘and’ in lists: straightforward ones (he ate ham, eggs and chips) do not need one, but sometimes it can help the reader (he ate cereal, kippers, bacon, eggs, toast and marmalade, and tea).”
On the occasions when the issue might crop up I can generally find a way of writing it to avoid any confusion. The Guardian’s example is not a good one as it appears to suggest that he ate tea which, of course, he didnt , as he drank it. It would very easily be rewritten.