I gave up growing lots of vegetables because of aphids and flea beetles. Lots of farmers recommended insecticidal soap to me. I tried everything you did, as well as nematodes (i think that was for flea beetles) and many other solutions. As for cukes mildew, I also gave up on those, too. It seemed like it was working at first, but then it didnt. The master gardener at our local farmers market told me it was probably because I planted the cukes too early or I used the wrong fertilizer. If you find solutions, please post back. I know how exhausting it can be to weed by hand and try to “naturally” maintain a garden, and mine still doesn’t look great. Sometimes I think I should just spray Seven and RoundUp and call it a day.