Ozempic, Wegovy, GLP-1 meds / compounded semaglutide

Did you watch the South Park special on Ozempic?

I found it pretty entertaining, but humor is, of course, highly subjective :wink:

Nope. I loved South Park because it seems nothing is sacred there, but haven’t seen it (or much of anything) in years.

I found this short clip - Randy gets shamed into trying it and now is convinced it’s the best thing ever.

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It’s just 40min long. As with most SP epis, it’s a bit… over the top :smiley:

But anything featuring Randy is going to be good, and The Bare Midriff Ladies are a hoot.

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After seeing that SP video, I realize that I have been using Ozempic all wrong.
LOL!

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Since these drugs haven’t been tested for long term use, hope is what we have.

Phen Fen, ephedra, human gonadotropin, HGH had high hopes, too. Not to mention crazy nutrition theories.

Everyone wants what they want, immediately and without effort or discomfort. Why diet and exercise when you can pop a pill that will slim you down and put you among the cool kids?

Again, there are undoubtedly patients whose conditions are so dire that this kind of intervention is an acceptable gamble. My own hope is that society gets its nutritional and exercise acts together, and these drugs are only need by a few.

Ha, that’s rich. Not like the furtive GLP users aren’t furtively judging the obese.

That’s a nice thought, but that is never going to happen. Not with the food industry & lobbies here who put sugar and crap in everything, with snacks and XXL-sized food bags everywhere, not with food deserts, food insecurity, and malnutrition.

As long as those factors aren’t also dealt with, you’re expecting a lot from the individual. The proverbial boot straps do not exist in a vacuum.

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Yeah, yeah, we’re all doomed by Big Ag, Big Insurance and Big Pharma and their ilk.

In reality, everyone has some bootstraps to pull themselves up by. All it takes is eyes to see and a little learning.

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That was an interesting video. His emphasis on weight gain after stopping the use of GLP-1 type drugs is an important factor for me. So far, I only take Ozempic for 7 or 8 weeks at a time and then take 5 or 6 weeks off. But my dosage has creeped up since I started in August of last year and is up to almost 1.5MG now that I have started my third pen. But on the up side, I only regained 3 pounds in 6 weeks I was off Ozempic and traveling. It will be interesting to see if I lose as much, or any, weight now that I am back at home with all the food temptations and doing less walking.
I am still 23 pounds below my highest weight from early August of last year and I am feeling much better, plus I am out of Atrial Fibrillation (super high heart rate) entirely. The Afib may have been weight related so it was another factor that has motivated me to recently buy my third pen.
This thread (and the video just above) have all been useful for me to consider the pros and cons of taking the drug. It has also added to my motivation to keep working every day on my Peloton, walking more again and to start looking for dumb bells to lift with, since I do not have a good gym nearby.

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I am not a doctor, and I don’t even pretend to be one, but the best way to lose weight and keep it off is to maintain and (if possible) build muscle.

Especially with drugs like GLP-1, where you are calorie inhibited, you tend not only to lost just weight, but muscle (which is inevitable since weight is basically muscle tissue, adipose tissue and skeletal mass).

And we all get older, it’s not only important to maintain muscle mass for overall health, but just for basic movement and dexterity (i.e., getting up without falling down).

And as muscle is naturally more metabolically expensive than adipose tissue, more muscle equals easier weight maintenance, if not easier weight loss.

So if you want a bit of unsolicited advice, ease up on the Peloton, and throw in a few more sessions with the dumbells, or just bodyweight exercises (like push ups, pull ups etc.)

In any event, enough rambling from me, good luck on your weight management journey.

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Up until Covid I lifted 3 to 4 times a week for more than 30 years. Golds Gym Arlington’s closure in March of 2020 hit me harder than any other aspect of epidemic.
But once I got out of the gym habit, it has been hard to get back into lifting. I have joined three gyms since then but never got the endorphin high again, or the lifting habit back. I have never been good at lifting at home, but the Peloton has become my morning ritual. Besides, I am crushing big time on the Peloton workout leader, Ally Love. I cannot imagine not taking at least one of her classes every week. LOL!

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I bet your FTP is something in the 5’s!

Weightlifting could be dangerous for people with heart disease.

Push-ups, sit-ups, planking, shoveling snow, digging earth, and archery can also be dangerous for people with heart disease.

I have tried explaining this to personal trainers and it does not compute.

If one has no heart disease, no valve issues, no blood pressure issues, lift away.

If one has heart disease, or has recovered from angioplasty or surgery, check with one’s cardiologist, cardiac surgeon and or family doctor before weight training.

Obviously people with heart disease should consult with their doctors but I have heard the exact opposite that they should incorporate weight exercise in their routine

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It depends on the type or heart disease.

If one has valve disease, it’s not advisable to overexert oneself. Stretch those valves a little too much and boom. Aneurysm. If one already is living with a faulty valve, and wants to avoid heart surgery, avoiding over exertion is a good idea.

The whole premise of weight training seems to be to over exert oneself, at least from the personal trainers I’ve met here in Canada over the past 30 years.

I can’t tell you how many middle-aged people I know have hurt themselves at the gym because a personal trainer gave them bad instructions or poor advice. I guess ill- guided personal training helps make work for some surgeons and physiotherapists. I know someone who had to have her rotator cuff repaired surgically because her trainer encouraged her to lift a stupid amount of weight for an out of shape middle-aged person.

There’s a lot of soft science in the exercise and wellness business.

But that’s a significantly smaller set of the disease area - before you mentioned people in general with heart disease should avoid weight lifting. Valve diseases are just a subset and outside of that set weight training isn’t an issue

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I am also not a doctor.

I think anyone with heart disease of any kind should avoid weight training until their family doctor , cardiologist, and cardiac surgeon if they have one, have told them they should weight train.

Weight training with atherosclerosis would also be ill advised, too.

It’s the spikes in blood pressure that are the issue.

Every time I’ve hired a personal trainer, they have encouraged me to do lifting that would result in spikes of blood pressure.

I’m tempted to check the case law to see if any personal trainers have been sued in Canada or the States, for encouraging a client to do exercises that ultimately led to an aneurysm or heart attack.

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There is plenty of literature and recommendations saying the opposite

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Obviously people should consult with a medical
professional before beginning any sort of dietary or medical regime.

But I think it is safe to say that pound for pound muscle is more metabolically expensive than fat.

How one achieves more muscle optimally and safely is certainly open for discussion, however.

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